Unlocking the "Longevity Vitamin": New Clinical Trials Affirm L-Ergothioneine's Role in Skin Health and Beyond

Table of Contents

1. Key Highlights:
2. Introduction:
3. The Genesis of Ergothioneine: From Fungus to Fundamental Micronutrient
4. L-Ergothioneine: A Shield Against Oxidative Stress and Inflammation
5. The "Longevity Vitamin": Redefining Essential Nutrients
6. A Nutrient for Radiant and Resilient Skin: The Topical and Oral Revolution
7. Dr.Ergo®: New Clinical Evidence for Superior Skin Health
8. Uncompromising Quality and Safety: The Dr.Ergo® Standard
9. EGT Synbio and Abinopharm: Leading the Charge in Longevity Ingredients
10. The Broader Implications: L-Ergothioneine in the Longevity Landscape
11. FAQ:

Key Highlights:

• Two new human clinical trials confirm the efficacy of oral L-ergothioneine (Dr.Ergo®) for significant improvements in multiple skin health parameters, including brightness, elasticity, and reduction in wrinkles and spots.
• L-ergothioneine, often dubbed the "longevity vitamin," is a powerful, naturally occurring antioxidant with a specific human transporter (OCTN1) facilitating its accumulation in vital organs and tissues, including the skin.
• Beyond dermatological benefits, L-ergothioneine plays a crucial role in cellular protection, particularly within mitochondria, supporting cognitive function, mitigating inflammation, and potentially slowing the aging process.

Introduction:

The quest for enhanced longevity and radiant skin has long driven scientific inquiry and consumer interest. From ancient remedies to cutting-edge biochemical discoveries, humanity consistently seeks ways to defy the visible and invisible tolls of time. In this pursuit, a fascinating molecule known as L-ergothioneine (EGT) has emerged from relative obscurity to a position of significant scientific attention. First isolated over a century ago, L-ergothioneine's full biological significance remained largely unappreciated until recent decades. Now, pioneering research positions it not merely as another antioxidant but as a "longevity vitamin" – a micronutrient crucial for long-term health, cellular protection, and healthy aging. The latest clinical trials, spearheaded by EGT Synbio and its U.S. partner Abinopharm, Inc., specifically highlight its remarkable efficacy in improving skin health, providing compelling evidence for its "beauty-from-within" potential. These developments underscore a paradigm shift in understanding how targeted nutritional interventions can profoundly impact both our external appearance and internal well-being.

The Genesis of Ergothioneine: From Fungus to Fundamental Micronutrient

The story of L-ergothioneine begins in 1909 with French chemist Charles Tanret, who successfully isolated the compound from the ergot fungus, Claviceps purpurea. This origin gave the molecule its distinctive name: "ergo" from ergot and "thioneine" to denote its sulfur-containing chemical structure. For many years following its discovery, L-ergothioneine remained a biochemical curiosity, its precise role in human physiology largely a mystery. Scientists observed its presence in various plants and animals, yet recognized a crucial limitation: neither plants nor animals could synthesize it themselves. This meant that L-ergothioneine had to be acquired exogenously, primarily from fungi—especially common culinary mushrooms like shiitake, maitake, and oyster mushrooms, which are rich sources, providing 10–13 mg per 100 g of dry weight—and certain bacteria. This dependency on external sources hinted at its potential importance, but the mechanism and extent of its biological impact remained elusive.

The turning point arrived in 2005 with a groundbreaking discovery by Professor Günther Gündemann. He identified a specific human transporter protein, OCTN1 (SLC22A4), which is solely dedicated to facilitating the uptake and accumulation of L-ergothioneine within the human body. This discovery was a revelation, elevating L-ergothioneine from a mere dietary compound to a highly selective and actively managed micronutrient. The presence of a dedicated transporter signaled that the body not only recognized L-ergothioneine but actively sought to concentrate it in a wide array of human tissues. Subsequent research revealed high concentrations in critical organs and systems, including bone marrow, liver, kidneys, red blood cells, the brain, eyes, and, significantly, the skin. This widespread distribution, facilitated by a unique transport mechanism, suggested a profound and multifaceted role in human health, setting the stage for deeper investigations into its protective and reparative properties.

L-Ergothioneine: A Shield Against Oxidative Stress and Inflammation

Following the identification of its dedicated transporter, the true biological significance of L-ergothioneine began to unravel. A pivotal contribution came from Professor Barry Halliwell, a preeminent authority in the study of reactive oxygen species (ROS) and oxidative stress. Professor Halliwell’s research identified L-ergothioneine as one of the most potent natural antioxidants known to science. This distinction is critical because oxidative stress—an imbalance between the production of free radicals and the body's ability to counteract their harmful effects—is a fundamental driver of aging and a myriad of chronic diseases. Free radicals are highly reactive molecules that can damage cellular components, including lipids, proteins, and DNA, leading to cellular dysfunction and tissue damage. L-ergothioneine’s exceptional antioxidant capacity allows it to effectively neutralize these harmful species, thereby mitigating oxidative damage throughout the body.

Beyond its direct antioxidant action, L-ergothioneine also demonstrates significant anti-inflammatory effects. Inflammation, particularly chronic low-grade inflammation, is another pervasive factor contributing to a wide range of age-related conditions. By reducing inflammatory pathways, L-ergothioneine offers a dual-action protective mechanism. This comprehensive cellular defense makes it a compelling therapeutic target for conditions where oxidative stress and inflammation are key pathological features. Scientific studies have elucidated its role in safeguarding against neurodegenerative diseases such such as Alzheimer’s and Parkinson’s, where neuronal damage is closely linked to oxidative stress. It also shows promise in cardiovascular disorders, protecting blood vessels and heart tissue from inflammatory damage, and in liver disease, where it helps maintain liver cell integrity and function.

Crucially, research has also highlighted L-ergothioneine’s high bioavailability and a remarkably long half-life within the human body. This means that when consumed, it is readily absorbed and remains active in the system for an extended period, allowing for sustained cellular protection. Its ability to accumulate specifically within mitochondria—the powerhouses of the cell responsible for energy production—is particularly significant. Mitochondria are highly susceptible to oxidative damage due to their intense metabolic activity. By protecting mitochondrial function, L-ergothioneine helps maintain overall cellular vitality, supporting cognitive function, enhancing cellular resilience, and contributing to healthy longevity. This multifaceted protective role underscores why L-ergothioneine is garnering increasing recognition as an indispensable micronutrient for maintaining health across the lifespan.

The "Longevity Vitamin": Redefining Essential Nutrients

The accumulating evidence for L-ergothioneine's profound biological impact led to a significant proposition in 2018 from renowned biochemist Professor Bruce Ames. Known for his pioneering work on aging and nutrition, Professor Ames suggested that L-ergothioneine should be classified as a "longevity vitamin." This concept extends beyond the traditional definition of essential vitamins, which are strictly required for immediate survival and the prevention of acute deficiency diseases. Instead, a "longevity vitamin" is understood as a micronutrient that, while not immediately life-sustaining, is absolutely vital for long-term health and for mitigating the effects of aging. Professor Ames posited that consistently low levels of L-ergothioneine in the diet might accelerate the aging process and significantly increase an individual’s susceptibility to chronic diseases.

This classification is not merely academic; it has profound implications for public health and dietary recommendations. If L-ergothioneine is indeed a "longevity vitamin," then ensuring adequate dietary intake becomes as crucial as consuming traditional vitamins and minerals for optimal health. The hypothesis suggests that while the body can function without sufficient L-ergothioneine in the short term, the cumulative effects of its deficiency over decades could manifest as premature aging, increased cellular damage, and a higher incidence of age-related pathologies.

The concept of a "longevity vitamin" challenges the conventional understanding of nutritional requirements. It moves beyond preventing overt deficiency diseases to promoting optimal cellular function and resilience throughout the human lifespan. This paradigm shift encourages a more proactive approach to nutrition, focusing on maintaining robust health and delaying the onset of age-related decline, rather than simply avoiding immediate illness. For L-ergothioneine, this means recognizing its role not just as a powerful antioxidant, but as a fundamental component of a diet aimed at fostering healthy aging and extending healthspan. The implications of Professor Ames's proposition continue to drive research into L-ergothioneine's long-term health benefits, potentially leading to new dietary guidelines and recommendations for supplementation, particularly for populations with insufficient mushroom intake.

A Nutrient for Radiant and Resilient Skin: The Topical and Oral Revolution

The broad protective capabilities of L-ergothioneine, particularly its antioxidant and anti-inflammatory properties, naturally extend to skin health. The skin, as the body’s largest organ, is constantly exposed to environmental stressors such as UV radiation, pollution, and chemical irritants, all of which generate oxidative stress and inflammation. These factors are primary contributors to premature skin aging, often referred to as photoaging. L-ergothioneine emerges as a multifunctional skincare nutrient, offering a comprehensive suite of benefits for maintaining a healthy, youthful complexion.

Its primary role in skin is its potent antioxidant power. By neutralizing free radicals generated by UV exposure and environmental pollutants, L-ergothioneine protects vital skin cell components—lipids, DNA, and proteins—from oxidative damage. This protection is crucial for preventing the breakdown of collagen and elastin, the structural proteins responsible for skin firmness and elasticity, and thus helps prevent the formation of sunspots, fine lines, and wrinkles. Its anti-inflammatory effects further benefit the skin by soothing redness and irritation often associated with conditions like acne, eczema, and general skin sensitivity. For those struggling with uneven skin tone or dullness, L-ergothioneine can promote a more even complexion and enhance overall skin radiance by mitigating the processes that lead to hyperpigmentation and oxidative dullness. Furthermore, studies suggest it supports collagen synthesis, enhancing skin elasticity, and contributes to improved skin hydration, both of which are fundamental for a plump, smooth, and resilient skin barrier.

While L-ergothioneine has been incorporated into topical cosmetic products for years, capitalizing on its direct protective effects at the skin's surface, the burgeoning interest lies in its oral application. The concept of "beauty-from-within" has gained significant traction, recognizing that skin health is intricately linked to internal nutritional status. In 2024, a Japanese clinical study provided compelling evidence for L-ergothioneine’s efficacy as an oral beauty ingredient. Participants who consumed a daily hiratake (oyster mushroom) tablet containing 25 mg of ergothioneine experienced statistically significant improvements in facial skin moisture and overall skin condition. This study was a crucial step, demonstrating that oral intake of L-ergothioneine could deliver tangible benefits to skin health, laying the groundwork for more extensive clinical investigations into its systemic effects. The promise of L-ergothioneine in both topical and oral formulations positions it as a versatile and powerful ally in the pursuit of comprehensive skin health and anti-aging strategies.

Dr.Ergo®: New Clinical Evidence for Superior Skin Health

Building upon the growing body of evidence supporting L-ergothioneine’s benefits, Abinopharm and EGT Synbio have recently unveiled the results of two human clinical trials specifically evaluating the efficacy of Dr.Ergo® L-ergothioneine for skin health. These trials provide robust, scientific validation for the product’s ability to deliver significant dermatological improvements when taken orally.

The first study was an open-label trial conducted in China in 2023. This trial involved nineteen healthy participants who consumed 25 mg of Dr.Ergo® daily for a period of four weeks. Dermatological assessments, utilizing the advanced VISIA imaging system, revealed visible and consistent improvements across several key skin parameters. Participants showed reductions in the appearance of skin pores, diminished wrinkles, and a decrease in both UV spots and brown spots, indicative of improved skin clarity and reduced photo-damage. Furthermore, a reduction in porphyrins—compounds associated with bacterial activity often linked to acne—was observed. Crucially, throughout the trial, no adverse effects were reported, underscoring Dr.Ergo®’s safety profile. The findings from this initial trial were published in the American Journal of Biomedical Science & Research, providing a preliminary but promising indication of L-ergothioneine’s skin-enhancing capabilities.

The second and more rigorous study was a double-blind, placebo-controlled trial conducted in Japan in 2024 by the Japan Clinical Trial Association (JACTA). This gold-standard study enrolled 66 healthy women aged 35 to 59, who were randomly assigned to receive either 30 mg of Dr.Ergo® daily or a placebo over an 8-week period. To ensure objectivity, skin parameters were meticulously measured using scientific instruments, complemented by participant questionnaires. The parameters assessed included skin brightness, tone, melanin levels, erythema (redness), gloss, elasticity, and the presence of spots.

After eight weeks of supplementation, the results were statistically significant and highly compelling (p < 0.01). Participants in the Dr.Ergo® group demonstrated significant improvements in multiple dimensions of skin health. They exhibited enhanced skin brightness and elasticity, indicating a more youthful and resilient complexion. Melanin levels showed beneficial changes, suggesting a reduction in hyperpigmentation, while erythema levels decreased, pointing to reduced skin inflammation and redness. Furthermore, measurable reductions in wrinkles and an increase in skin gloss were observed, reflecting improved skin texture and hydration. Consistent with the open-label trial, no significant adverse events were reported, reinforcing the safety and tolerability of Dr.Ergo®. Details of this comprehensive study are publicly available on ClinicalTrials.gov under the identifier NCT06886061, allowing for transparency and verification of the findings. These two clinical trials collectively provide robust scientific validation for the oral intake of Dr.Ergo® L-ergothioneine as an effective strategy for achieving healthier, more radiant, and resilient skin from within.

Uncompromising Quality and Safety: The Dr.Ergo® Standard

The efficacy and safety of any nutritional supplement are paramount, particularly when dealing with ingredients intended for daily consumption and long-term health benefits. Dr.Ergo® L-ergothioneine stands out due to its unwavering commitment to quality and safety, backed by rigorous manufacturing standards and multiple international certifications. This dedication ensures that consumers receive a pure, potent, and safe product.

The production of Dr.Ergo® utilizes a patented full enzymatic fermentation process (EP 4520819A1). This advanced biotechnological method allows for the creation of L-ergothioneine in a highly controlled environment, ensuring consistency and purity. The entire manufacturing process adheres strictly to current Good Manufacturing Practice (cGMP) standards, which are regulatory guidelines designed to ensure that products are consistently produced and controlled according to quality standards. These standards minimize the risks involved in any pharmaceutical production that cannot be eliminated through testing the final product.

Beyond cGMP, Dr.Ergo® has achieved a host of critical certifications that underscore its high-quality profile:

• U.S. FDA GRAS (Generally Recognized as Safe) Status: This designation from the U.S. Food and Drug Administration signifies that qualified experts generally consider the substance safe for its intended use, a crucial endorsement for a dietary ingredient.
• NSF GMP Certification: NSF International is a global public health organization that certifies products and writes standards for food, water, and consumer goods. NSF GMP certification ensures that facilities meet strict quality and safety standards for manufacturing.
• HACCP Compliance: Hazard Analysis and Critical Control Points (HACCP) is a systematic preventive approach to food safety from biological, chemical, and physical hazards in production processes that can cause the finished product to be unsafe.
• HALAL Certification: This certification indicates that the product adheres to Islamic dietary laws, ensuring it is prepared and processed according to specific purity and quality requirements, making it accessible to a broader consumer base.

Furthermore, Dr.Ergo® adheres to ICH quality guidelines, an internationally recognized set of harmonized standards for pharmaceutical development and manufacturing. This commitment to international best practices is reflected in the product’s exceptional purity, with both purity and optical purity exceeding 99.9%. This high level of purity is critical as it minimizes the presence of inactive or potentially harmful contaminants. To further ensure consumer safety, all impurities, heavy metals, and microbial levels are meticulously controlled and maintained within strict USP (United States Pharmacopeia) limits. USP standards are official standards for the quality and purity of medicines and health products, offering an additional layer of assurance regarding the product’s integrity.

This comprehensive array of certifications and adherence to stringent quality control measures not only ensures the safety and efficacy of Dr.Ergo® but also solidifies its position as a premium, trustworthy L-ergothioneine product on the global market. Consumers can have confidence that Dr.Ergo® is manufactured to the highest possible standards, delivering a pure and effective ingredient for their health and wellness needs.

EGT Synbio and Abinopharm: Leading the Charge in Longevity Ingredients

The successful clinical validation and market availability of Dr.Ergo® L-ergothioneine are the result of a strategic partnership between two innovative companies: EGT Synbio and Abinopharm, Inc. Both entities are at the forefront of biological solutions for anti-aging and premium health products, bringing together specialized expertise in ingredient development, manufacturing, and distribution.

EGT Synbio, headquartered in Shanghai, China, has established itself as a pioneer in developing cutting-edge biological compounds aimed at combating the effects of aging. Their scientific team is dedicated to the research, development, and clinical validation of advanced ingredients that address the complex mechanisms of aging at a cellular level. Dr.Ergo® L-Ergothioneine is a flagship product, recognized globally as a premium, odorless, and stable crystalline ingredient. Its widespread adoption by leading global brands across various sectors, coupled with its certifications by U.S. GRAS, EU Novel Food, and NSF, attests to its quality and market acceptance. EGT Synbio’s innovation extends beyond L-ergothioneine; in 2024, the company significantly expanded its portfolio with the launch of EquoPro™ (S)-Equol and Dr.SPD™ Spermidine Hydrochloride. These additions broaden their offerings in critical areas of dietary supplements, skincare, and pharmaceuticals, solidifying their position as a key provider of advanced ingredients for functional foods, luxury beauty products, and medical-grade nutrition. Their commitment to scientific rigor and product diversification positions them as a significant player in the global longevity market.

Abinopharm, Inc., based in Shelton, Connecticut, USA, serves as EGT Synbio’s exclusive U.S. collaborator and distributor for Dr.Ergo® L-ergothioneine. Abinopharm is a U.S.-based nutritional and biopharmaceutical company with a dual focus: developing, manufacturing, and commercializing premium health products within the U.S. and on a global scale. Their nutritional division is particularly specialized in longevity ingredients, forging strong partnerships with leading academic institutions and industry experts to bring cutting-edge research to practical applications.

Abinopharm’s commitment to scientific validation is exemplified by their other flagship ingredients. Their NMN ingredient (AbinoNutra® NMN) holds Self-Affirmed GRAS status and has undergone clinical validation in collaboration with Professor Andrea Maier, a prominent researcher in the field of aging. In addition to L-Ergothioneine (Dr.Ergo®) and NMN, their comprehensive portfolio of anti-aging and health-promoting ingredients includes Fisetin (BeFisetin®), Urolithin A, CaAKG, Spermidine (Dr.SPD™), S-Equol (EquoPro™), and Hydroxytyrosol. This extensive range positions Abinopharm as a holistic provider of ingredients targeting various pathways of aging and cellular health. The finished product, known as AbinoNutra® NAD+, which likely incorporates many of these advanced ingredients, is readily available online through their website, www.abinonutra.com, and on Amazon. The synergistic efforts of EGT Synbio in innovation and Abinopharm in commercialization and distribution are collectively driving the awareness and accessibility of these vital longevity ingredients to a global audience, empowering individuals in their pursuit of enhanced health and well-being.

The Broader Implications: L-Ergothioneine in the Longevity Landscape

The recent clinical trial successes of Dr.Ergo® L-ergothioneine for skin health not only bolster its standing in the cosmeceutical market but also reinforce the broader scientific understanding of its role as a "longevity vitamin." The intricate connection between oxidative stress, inflammation, and cellular aging means that a compound capable of effectively addressing these factors has implications far beyond surface-level aesthetics. L-ergothioneine’s ability to accumulate in various critical tissues, facilitated by its specific transporter OCTN1, suggests a systemic protective effect that contributes to overall healthspan, not just lifespan.

Consider the brain, where L-ergothioneine is concentrated. Its neuroprotective qualities, derived from its powerful antioxidant capacity, are vital in mitigating damage linked to neurodegenerative conditions like Alzheimer's and Parkinson's diseases. By protecting neuronal cells from oxidative insults and reducing neuroinflammation, L-ergothioneine contributes to maintaining cognitive function and neural resilience as individuals age. Similarly, its presence in the liver and kidneys highlights its role in supporting crucial detoxification and filtration processes, protecting these metabolically active organs from damage and ensuring their long-term function.

The emphasis on L-ergothioneine’s function within mitochondria is particularly compelling. Mitochondria are the primary sites of energy production, and their efficiency and integrity are directly linked to cellular vitality and the aging process. Mitochondrial dysfunction is a hallmark of many age-related diseases. By safeguarding these cellular powerhouses from oxidative stress, L-ergothioneine ensures more efficient energy production and reduces the generation of harmful byproducts, thereby supporting overall cellular health and delaying cellular senescence. This fundamental protection at the cellular level is what underpins its classification as a "longevity vitamin" by Professor Bruce Ames.

The increasing body of evidence around L-ergothioneine, including these new skin health trials, underscores a growing trend in nutritional science: the focus on highly targeted micronutrients that offer multi-system benefits. As research continues to unravel the complexities of aging, ingredients like L-ergothioneine are becoming indispensable in formulating comprehensive health strategies. These strategies move beyond simply preventing acute deficiencies to actively promoting cellular resilience, delaying the onset of chronic age-related diseases, and enhancing the quality of life well into later years. The developments surrounding Dr.Ergo® thus serve as a powerful testament to the potential of science-backed nutritional interventions to redefine healthy aging and unlock new avenues for vitality.

FAQ:

Q1: What exactly is L-ergothioneine and where does it come from? A1: L-ergothioneine is a unique, naturally occurring amino acid derivative containing sulfur. It was first isolated from the ergot fungus. While found in many plants and animals, these organisms cannot synthesize it themselves. Humans primarily obtain L-ergothioneine from their diet, with mushrooms—such as shiitake, maitake, and oyster mushrooms—being particularly rich sources. Certain bacteria also produce it.

Q2: Why is L-ergothioneine considered a "longevity vitamin"? A2: Professor Bruce Ames proposed L-ergothioneine as a "longevity vitamin" because, while not essential for immediate survival, it is crucial for long-term health and healthy aging. It has a dedicated human transporter (OCTN1) that concentrates it in vital tissues, where it acts as a potent antioxidant and anti-inflammatory agent. Low levels may accelerate aging and increase the risk of chronic diseases by failing to protect cells from oxidative damage and inflammation, particularly in mitochondria.

Q3: How does L-ergothioneine benefit skin health, according to the new clinical trials? A3: The new clinical trials on Dr.Ergo® L-ergothioneine demonstrated significant improvements in several skin parameters. These include increased skin brightness, enhanced elasticity, reduced melanin levels (suggesting fewer spots), decreased erythema (redness), fewer wrinkles, and improved skin gloss. These benefits stem from L-ergothioneine's ability to protect skin cells from oxidative damage, reduce inflammation, and support collagen synthesis and hydration, combating the signs of photoaging and promoting overall skin resilience.

Q4: Are there specific clinical studies supporting the efficacy of Dr.Ergo® L-ergothioneine for skin? A4: Yes, two recent human clinical trials confirm its efficacy. An open-label trial in China (2023) showed improvements in skin pores, wrinkles, UV spots, brown spots, and porphyrins in 19 participants taking 25 mg daily for four weeks. A more robust double-blind, placebo-controlled trial in Japan (2024) involved 66 healthy women taking 30 mg daily for 8 weeks, revealing statistically significant improvements in brightness, elasticity, melanin, erythema, wrinkles, and skin gloss.

Q5: What makes Dr.Ergo® L-ergothioneine a high-quality and safe product? A5: Dr.Ergo® is produced using a patented full enzymatic fermentation process under strict cGMP (current Good Manufacturing Practice) standards. It has achieved U.S. FDA GRAS (Generally Recognized as Safe) status, NSF GMP certification, HACCP compliance, and HALAL certification. The product also adheres to ICH quality guidelines, boasting purity and optical purity greater than 99.9%, with all impurities, heavy metals, and microbial levels controlled within USP (United States Pharmacopeia) limits. These rigorous standards ensure its safety, purity, and quality.

Q6: Beyond skin health, what other benefits does L-ergothioneine offer? A6: L-ergothioneine provides widespread cellular protection, particularly in the bone marrow, liver, kidneys, red blood cells, brain, and eyes. Its potent antioxidant and anti-inflammatory properties help mitigate oxidative damage and inflammation, which are factors in conditions such as neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s), cardiovascular disorders, and liver disease. It also supports mitochondrial health, helping to maintain cognitive function, enhance cellular resilience, and contribute to overall healthy longevity.

Q7: How does L-ergothioneine compare to other antioxidants? A7: L-ergothioneine stands out due to its unique, dedicated human transporter (OCTN1), which allows the body to actively absorb and concentrate it in specific tissues. This selective accumulation, combined with its high bioavailability and long half-life, suggests it offers targeted and sustained protection against oxidative stress and inflammation, making it exceptionally effective compared to many other antioxidants that may not be as efficiently distributed or retained in the body.

Q8: Can L-ergothioneine be obtained from diet alone, or is supplementation recommended? A8: While L-ergothioneine is found in significant amounts in certain mushrooms (e.g., shiitake, maitake, oyster), dietary intake can vary widely based on individual eating habits. The proposition that it is a "longevity vitamin" suggests that consistent and adequate intake is vital for long-term health. For individuals who do not regularly consume high amounts of ergothioneine-rich foods, supplementation, such as with Dr.Ergo®, may be a beneficial strategy to ensure optimal levels and support healthy aging.

Q9: Who are EGT Synbio and Abinopharm, Inc.? A9: EGT Synbio is a pioneering biopharmaceutical company based in Shanghai, China, specializing in biological solutions for anti-aging and developing clinically validated compounds like Dr.Ergo® L-Ergothioneine. Abinopharm, Inc. is its exclusive U.S. collaborator and distributor, a nutritional and biopharmaceutical company based in Shelton, Connecticut, focused on developing and commercializing premium health products and longevity ingredients in the U.S. and globally. They partner to bring innovative ingredients to the market.